[1] It is located five nautical miles (9 km) north of the central business district of Jeffersonville, Indiana,[1] in the town of Sellersburg.

These FBOs, COs, and MAOs employ many full-time and part-time employees, contributing to the economic growth of the surrounding communities.

The commercial businesses that have and continue to relocate to the expanding River Ridge Commerce Center will find Clark Regional Airport's convenient and easily accessible location is ideal for their corporate travel and industrial shipping needs.

Clark Regional Airport, through land acquisitions partially funded by the Federal Aviation Administration (FAA) and Indiana Department of Transportation (INDOT), has increased its footprint for future development of the surrounding property, making it an ideal location for the booming Southern Indiana economic and industrial growth that the region is currently experiencing.

[1] For the 12-month period ending December 31, 2010, the airport had 67,922 aircraft operations, an average of 186 per day: 88% general aviation and 12% air taxi.