It developed between about 1840 and 1930, and includes representative examples of Greek Revival, Italianate, and Queen Anne style architecture.

Located in the district is the separately listed Clifford-Wyrick House.

Other notable buildings include the City Hall (1910), Sentinel Building (1867-1871), Clifford Banking Company (c. 1887), La Crosse Lumber Company (1923), Presbyterian Church, Methodist Church (1906), Masonic Temple (1903), and Clarksville Public Library (1910).

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