The Clarksville Historic District is a national historic district located at Clarksville, Mecklenburg County, Virginia.

Notable buildings include the Planters Bank (1909), Planters Brick Tobacco Sales Warehouse (c. 1840), Gilliland Hotel (c. 1900), the Russell's Furniture, former Clarksville High School (1934), Clarksville Presbyterian Church (c. 1832), Mount Zion Baptist Church (c. 1875), Jamieson Memorial Methodist Episcopal Church (1901), St. Timothy's Episcopal Church (1917), and St. Catherine of Siena Roman Catholic Church (1947).

Located in the district are the separately listed Clark Royster House and the Judge Henry Wood Jr.

[3] It was listed on the National Register of Historic Places in 2002.

This article about a property in Mecklenburg County, Virginia on the National Register of Historic Places is a stub.