In the main event, Kevin Owens defeated Seth Rollins to retain the WWE Universal Championship.

The event was established on a similar concept as Night of Champions, with every title exclusive to Raw at the time defended.

[5] However, he was forced to vacate the championship the next night on Raw due to suffering a legit shoulder injury during the match.

Raw general manager Mick Foley then scheduled Owens to defend his championship against Rollins at Clash of Champions.

[5] Having been deprived of his chance at the WWE Universal Championship in the four-way elimination match, Reigns confronted Owens on the September 5 episode of Raw.

Foley then restarted the match, but Rusev came down to the ring and distracted Reigns, allowing Owens to score a pinfall.

[10] At SummerSlam, The New Day (Kofi Kingston and Xavier Woods) lost to Luke Gallows and Karl Anderson by disqualification when Big E returned from injury and interfered in the match.

Banks teased a retirement, but then revealed that she would be cleared to compete by Clash of Champions and invoked her rematch clause for the championship at the event.

[8] The next week, a confrontation between all four women led to a triple threat match to decide Charlotte's challenger at Clash of Champions.

[10] On the September 12 episode of Raw, Sami Zayn was the guest on Chris Jericho's "Highlight Reel".

Sheamus won the first three matches at SummerSlam and on the August 29 and September 5 episodes of Raw to lead the series 3–0.

[13] The actual pay-per-view opened with The New Day (Big E and Kofi Kingston) defending the Raw Tag Team Championship against Luke Gallows and Karl Anderson.

In the end, Xavier Woods struck Anderson with The New Day's trombone, allowing Big E and Kingston to execute the "Midnight Hour" on him to retain the title.

In the end, Charlotte executed a "Queen's Boot" to Bayley, knocking her into Banks, who was on the ring apron.

During the match, Reigns performed a spear on Rusev, only for Lana to pull the referee out of the ring, for which she was ejected from ringside.

[13] Seth Rollins suffered a legitimate rib injury stemming from Kevin Owens's Gutbuster off the second rope, leading to him not being medically cleared to compete.

[15][16] The following night, Raw opened with a rematch between Roman Reigns and Rusev for the United States Championship.

[17] The following week, Lana demanded another match, after which, Rusev attacked Reigns and tried to leave with the title belt, but Reigns attacked him with a Superman Punch and declared he would fight Rusev in a Hell in a Cell match, which was scheduled for Hell in a Cell.

[22] This would be the final Clash of Champions as the originally planned 2021 event was canceled and replaced by that year's Extreme Rules.