The Claude-Mélançon Ecological Reserve (in French: Réserve écologique CLaude-Mélançon) is an ecological reserve located in the municipality of Saint-Philémon, in Bellechasse Regional County Municipality (MRC), in administrative region of Chaudière-Appalaches, in Quebec, Canada.

The reserve protects a representative ecosystem of the Hautes-Appalaches and the hills of Mégantic, Etchemin Lake and Saint-Michel-du-Squatec.

[2] This reserve is located at about 60 km at the South-East of Quebec, between Mont Saint-Magloire (the highest point of the massif) and the ruisseau du Milieu.

Wildlife is found to be varied in the area, including moose, white-tailed deer, beaver, hare, fisher, bobcat, fox, coyote, black bear, American marten, ermine, river otter, American mink, squirrel, vole and shrew.

[1] The name of the reserve pays homage to Claude Mélançon (1895–1973), a naturalist who worked in the popularization of science.