Claude Mérelle was born Lise Henriette Marie Laurent in Colombes, France in 1888, she made her film debut in the 1912 short Les noces siciliennes, directed by Louis Feuillade.

[2] She would go on to appear in numerous film serials throughout the 1910s under the name Lise Laurent and directed by filmmakers such as Feuillade, Henri Pouctal and Henri Diamant-Berger before using the stage name Claude Mérelle beginning in 1918.

[3] Mérelle most often appeared in film serials throughout her career, such as 1924's Les aventures de Robinson Crusoé, directed by Gaston Leprieur; 1924's Les amours de Rocambole, directed by Charles Maudru; 1925's Jean Chouans, directed by Luitz-Morat; 1926's Le capitaine Rascasse, Henri Desfontaines and 1926's Le juif errant, directed by Luitz-Morat.

Her final film appearance was in the 1928 drama Rapa-Nui (also known as The Golden Abyss) directed by Mario Bonnard and starring André Roanne.

[4] Claude Mérelle was married to stage and film actor Albert Decoeur from 1923 until his death in 1942.