Claude Raymond Wickard (February 28, 1893 – April 29, 1967) was an American Democratic politician who served as the secretary of agriculture during the administrations of Presidents Franklin D. Roosevelt and Harry S. Truman from 1940 to 1945.

He graduated from Purdue University in 1915 with a bachelor's degree in agriculture, and he was chosen as "Master Farmer of Indiana" in 1927 for his improvements in stock feeding and farming.

When Henry A. Wallace resigned as the secretary of agriculture in September 1940 to run for Vice-President in the 1940 presidential election, Wickard was appointed to the post.

He was on the winning side in Wickard v. Filburn, in which the U.S. Supreme Court decided in a case that the federal government could control wheat that was grown in one state for the personal use of a farmer.

On January 18, 1943, Wickard banned the sale of presliced bread, possibly to save tools and wax paper, as required at the time.