During the 1970s, she interviewed female figures including performing artists Goldie Hawn and Loretta Lynn and congresswomen Patsy Mink and Eleanor Holmes Norton.
Over the course of her career, Dreifus' interviews and long-form narrative articles have appeared in Ms., The Nation, Playboy, Playgirl, The Progressive, Mother Jones, Cosmopolitan, Ladies Home Journal, New Woman, the liberal democrat, New York Post, Newsday, Parade, Penthouse, Present Tense, Redbook, and others.
[4] In 1999, Dreifus began to write the regular “Conversation with…” feature of the Tuesday Science Section of The New York Times.
[11] Interviewees have included Abraham Loeb,[12] 2012 Eric R. Kandel and Ruslan M. Medzhitov, in 2011 George Dyson, Jack W. Szostak, Daniel Lieberman, Stephen Hawking, Janet Rowley, in 2010 Jane Goodall, David Weatherall, Diana Reiss, Vanessa Woods, Elaine Fuchs, Jeffrey L. Bada, Sean M. Carroll, Peter Pronovost, Samuel Wang, in 2009 Frank A. Wilczek, Laurence Steinberg, Brian J. Druker, Carol W. Greider, Martin Chalfie, Paul Root Wolpe[13] Through this work for The New York Times Tuesday Science Section, Dreifus has become increasingly involved in writing about the lives and work of scientists.
[14] In 2006, Dreifus was named an Honorary Member of Sigma Xi for her ability to illuminate the work of scientists for a wide public.
She was nominated for the National Magazine Award of 1992 by TV Guide for TVs Censor from Tupelo, an investigative report on censorship.