Claysburg is a census-designated place (CDP) along Interstate 99 and the Allegheny Front in Blair County, Pennsylvania, United States, situated near the base of Blue Knob.

As of the census[5] of 2000, there were 1,503 people, 616 households, and 442 families residing in the CDP.

There were 653 housing units at an average density of 254.9 per square mile (98.4/km2).

25.6% of all households were made up of individuals, and 13.5% had someone living alone who was 65 years of age or older.

The town is the 1961 location of Claysburg Air Force Station (originally Blue Knob Park).