[1] On 18 February 2013 Clayson joined Ituano,[2] making his debut for the club on 24 March, coming on as a second-half substitute in a 1–2 home loss against Oeste for the Campeonato Paulista championship.

[3] He scored his first professional goal on 15 March 2015, netting his side's only in a 1–2 loss at Grêmio Osasco Audax.

[4] On 28 August 2015, Clayson signed for Série A club Ponte Preta, on loan until the end of the year.

[6] He established himself as a starter for the club during the season, and scored his first top tier goal on 3 June 2016 by netting the second in a 2–1 away win against América Mineiro.

[7] In June 2017, Clayson joined Corinthians, where he was part of the squad that won the 2017 Campeonato Brasileiro Série A.