[2] Clayton is located directly on the Mississippi River and is only accessible via a very steep road.

[4] According to the United States Census Bureau, the city has a total area of 0.49 square miles (1.27 km2), all land.

[5] As of the census of 2020,[7] there were 45 people, 30 households, and 18 families residing in the city.

There were 70 housing units at an average density of 136.3 per square mile (52.6/km2).

Hispanic or Latino persons of any race comprised 2.2% of the population.

There were 84 housing units at an average density of 171.4 per square mile (66.2/km2).

50.0% of all households were made up of individuals, and 14.2% had someone living alone who was 65 years of age or older.

There were 64 housing units at an average density of 116.2 per square mile (44.9/km2).

40.6% of all households were made up of individuals, and 21.9% had someone living alone who was 65 years of age or older.