Clayton is a town in northern Concordia Parish, Louisiana, United States.

Louisiana State Representative Andy Anders is from Clayton and Ferriday.

Among the businesses in the community are Cross Keys Bank and David's Grocery.

The last surviving brother, Howard Davis, died in 1972 and the gin continued to operate under the management of his son-in-law Sam D. Cole until his death in 1979.

Clayton is located in northern Concordia Parish at 31°43′8″N 91°32′20″W / 31.71889°N 91.53889°W / 31.71889; -91.53889 (31.718837, -91.538902),[3] along the south bank of the Tensas River.

[2] As of the 2020 United States census, there were 584 people, 189 households, and 107 families residing in the town.

The racial makeup of the town was 31.70% White, 67.25% African American, and 1.05% from two or more races.