Clayton Crain is an American comic book artist known for his digital painted work on Marvel Comics books such as Ghost Rider, X-Force, and Carnage, and also on the Valiant Comics series Rai.

Clayton Crain grew up in Moxee, Washington with his parents and older sister.

He was sketching on his schoolwork from a very early age and made the definitive choice to be a comic book illustrator at the age of 14 after seeing The Amazing Spider-Man #315.

[citation needed] Crain's career began with Acclaim Comics after he showed editor Fabian Nicieza a 5-page original story board of his artwork.

Crain works for Valiant Comics on the book Rai, with writer Matt Kindt.