Virgo is best known for co-writing and directing an adaptation of the novel by Canadian writer Lawrence Hill, The Book of Negroes (2015), a six-part miniseries that aired on CBC Television in Canada and BET in the United States.

[7] Starring Lauren Lee Smith and Eric Balfour, Lie With Me had its European premiere at the 2006 Berlin International Film Festival, Panorama Section.

Poor Boy's Game earned Virgo a nomination in 2007 for the Directors Guild of Canada Outstanding Achievement Craft Award for direction of a motion picture film.

In a review for Variety, critic Leslie Felperin praised the film's treatment of race, identity and sexuality, declaring it to be Virgo's best work up to that time.

[9] Virgo co-wrote and directed the six-part miniseries adaptation of Lawrence Hill's bestselling novel The Book of Negroes (2015), starring Aunjanue Ellis, Cuba Gooding Jr., Lou Gossett Jr., Ben Chaplin, Jane Alexander and Lyriq Bent.

[16] Virgo's television credits include The Wire for HBO, The L Word for Showtime, Baz Luhrmann's Netflix drama The Get Down (2016), and American Crime for ABC.

[21] In November 2021, he was announced as directing the upcoming Black Cyclone, a biopic on legendary cyclist Major Taylor, for Mind's Eye Entertainment.