[2] Clemson's Greek Life roster has now increased to 44 chapters on campus: fraternities and sororities from the National Panhellenic Conference, the North American Interfraternity Conference, the Multicultural Greek Council, and the National Pan-Hellenic Council.

However many fraternities operate large off-campus houses in or near the North Clemson Neighborhood adjacent to campus.

Popular off-campus activities that Greek life regularly and widely attend include Mountain Weekends (fall trips to mountain cabins hosted separately as a date function by each fraternity), Formals (fraternities usually host formal at a beach front location or large city while sororities tend to rent out ballrooms in the local upstate South Carolina area) and Carolina Cup (semi-annual horse race in spring in Camden, SC).

Panhellenic strives for "commitment to academics and service and our strong student presence in campus wide organizations and leadership positions."

MARYS House (Ministry Alliance for Regaining Your Safety) is the service project Panhellenic works on throughout the school year.

[5] IFC fraternities participate in rush twice a year in the fall and spring usually 1–2 weeks into each respective semester.

[8] The first National Pan-Hellenic Council organization chartered on the campus of Clemson University was Omega Psi Phi fraternity in 1974.

Each year the National Pan-Hellenic Council hosts the Fall Fest step show and week of service.

[5] This council is made up of five executive members and governs sororities and fraternities that are traditionally based on multicultural values.

Students in these sororities and fraternities work to spread awareness of Asian and Latino culture and to promote appreciation of diversity.

Order of Omega sponsors activities such as the Clemson Cup Speech Competition, Holiday Wishes Toy Drive and the Annual Fraternity and Sorority Life Awards Banquet.

[12] Clemson University currently does not offer sorority and fraternity houses on campus but does set apart certain residence halls for Greeks.

[13] The other sororities live in the Barnett and Smith residence halls in an area commonly referred to as "the horseshoe.