The company then began developing mainframe middleware in the 1980s, and with the rise of the PC, moved into B2B data communications and secure file transfer software.

Based in Rockford, Illinois (USA), with offices in Chicago, Pennsylvania, London, and Bangalore, Cleo has about 400 employees and more than 4,100 direct customers.

Cleo customers also include household brands such as New Balance, Barilla, Duraflame, Reddy Ice, and Brother Industries.

Cleo has partnerships with more than 300 system integrator, reseller, and technology companies including VAI, SrinSoft, Vertext, Remedi, and delaPlex.

In May 2023, Cleo announced it entered a global partnership with consulting and multinational information technology services company, Cognizant (NASDAQ: CTSH).

Together, the companies announced CCIB, powered by Cleo, which is a B2B iPaaS solution that provides B2B managed services with built-in, scalable infrastructure on the cloud.

More recent additions to the company's leadership team include Vipin Mittal,[21] Vice President, Customer Experience, and Tushar Patel,[22] CMO.

Cleo opened its product development facility in Bengaluru, India, in 2015[23] and expanded its hybrid cloud integration teams into a new office there in 2017.

[24] In 2016, Cleo acquired EXTOL International, a Pottsville, Pa.-based business and EDI integration and data transformation company for an undisclosed amount.