[8] Prior to its release in the United States, the series was first broadcast in Southeast Asia on DreamWorks Channel beginning on November 25, 2019.

[2][12][13] Cleopatra and her newfound friends work to try and return her to her own time, in Ancient Egypt, as she gains new combat skills in the process.

He also may have been influenced by Kipo and the Age of Wonderbeasts,[31] Avatar: The Last Airbender, Star Trek: The Next Generation, Buffy the Vampire Slayer, and Legends of Tomorrow.

[32] In an interview with Charles C. Dowd on I Heart Webcomics on July 22, Maihack said that he consulted in the early stages of the show, letting DreamWorks know the upcoming details of his book and remained supportive, admitting he did not want "a direct adaption of the novels.

Langdale explained how Egyptian history was an inspiration for many character names, sometimes by coincidence, and how Lilimar Herendez was the choice for the main role of Cleopatra from the beginning, while stating how Sendhil Ramamurthy, Jorge Diaz, and Katie Crown influenced the show through their voice acting.

[37] Jackson Murphy of Animation Scoop described the song as making it clear that Cleo's story is about "meaning, purpose and destiny.

"[1] In an August 13, 2020 interview with Sergio Burstein of the Los Angeles Times, Lilimar describes the show as the first thing she has done in the animation field, and was surprised to by their proposal for her to sing the title song.

[38] While she admitted she was nervous to sing the song at first, because she hadn't "done anything with music in ten years," she said that working on the show helped her regain her "voice as a singer," while encouraging her to do things out of her "comfort zone," and remained grateful of the positive responses on Twitter.

[41] She also explained the struggles with recording lines, how this show is the first time she has had such a big role, and its relevance during the COVID-19 pandemic with the main cast having to work together under extraordinary circumstances.

According to Langdale, the drawn-out visual development of the show allowed them to have a style close to Mailhack's original graphic novels.

In the interview, he described how he imagines the "shapes and colors of the characters based on the descriptions" he reads in a script or other document, saying that in draw something differently depending on the age of the audience, and the excitement of working collaboratively with others on various animated shows.

Furthermore, she said that the team she worked with, like Doug Langdale, and a voice director Sirena Irwin, made her feel excited and comfortable, as she explored the character and the world of the show.

In the same interview, she said that the experience was "nice," even as a new person to voice acting, adding that working with people who more skilled in the industry inspired and motivated her.

As they battle outside a Xerx fortess, Cleo gets separated and tries to join a tribe of very chill creatures which are avowed as nonviolent.

Khensu wants to make Cleo, Akila, and Brian into an official team, but they're having trouble working together – which Octavian uses to his advantage.

It's time for the No Science Fair and Cleo has decided to take this opportunity to find proof that Callie is Octavian's spy.

Mihos gets parasites, causing him a serious illness, so Cleo and her friends shrink to a tiny size to help heal him.

In the United States, NBCUniversal's advertisement sales website previously suggested that Cleopatra in Space would be broadcast on Universal Kids.

[6][4] Prior to the scheduled release in the United States, the series premiered on November 25, 2019 on DreamWorks Channel, which is available in Southeast Asia and select other areas of Asia Pacific (specifically, Hong Kong, Indonesia, South Korea, Malaysia, Maldives, Myanmar, the Philippines, Pakistan, Singapore, and Taiwan).

[80][81][82][83] On May 1, 2020, the entire first season of Cleopatra in Space was released on Globoplay, a Brazilian service and subsidiary of Grupo Globo, with the name Cleópatra no Espaço.

[51] On August 27, Bertrand Todesco called on Netflix France, and their main office in the United States, to broadcast the show outside the U.S., noting that "international fans" are asking about it every day, and that they could negotiate the rights with DreamWorks.

The entry praises the "nice background details" and calls the series fun, amusing, "brightly animated and engaging.

"[112] Courtney Lofty described the series as being about "badass women, talking cats, [and] space," noting that the overall vibe is a "classic Saturday morning cartoon, with extremely quotable moments" which is like Invader Zim.

[35] Cheryl Eddy on Gizmodo described the show as one aimed at children, but "looks like a fun ride for geeky grown-ups",[113] while Karen Han and Petrana Radulovic in Polygon[114] and Sam Stone on CBR[115] reviewed it positively.

Additionally, others described the show as "a fun take on the original Cleopatra story"[116] and a "comedic adventure" which focuses on Cleopatra's teenage years, where she is transported into the future "to an Egyptian-themed planet...ruled by talking cats" while dealing with the pressures of being "a teenager in high school" as she tries to fit in even as Octavian tries to kill her.

She described the series as wacky and vibrant, using its "zany concept effectively," having interesting adventures, and has main characters who have "typical stock cartoon personalities.

Radulovic also said that the "electronic-infused Egyptian melodies of the score" make it stand out, as do the outfits of the characters, while noting that the show is episodic like Gravity Falls rather than something like She-Ra and the Princesses of Power.

In an episode of Tooned Up on the Renegade Pop Culture Podcast, one of the guests described the show as having a stellar voice cast, sharp writing, which is "almost too self aware," while saying that they wished that the animation budget "was a little bit higher."

"[119] In contrast, Ashley Moulton on Common Sense Media rated the series 3 out of 5, noting that there is "a lot of fantasy violence," while saying that Cleopatra is a "fearless female lead," with her potential as a role model "offset by the fact that she can be impulsive, impatient, overconfident, and not so dedicated to her schoolwork," adding that there is "mild language...and flirtation," saying that the show isn't educational even though it "features a historical character.

"[120] Rather it is, in Moulton's view, focused on entertainment "in the vein of '80s Saturday morning cartoons," and she describes the series as "light, fun tween sci-fi" animation which explores the past and future, while praising the "interesting alien species, exciting fight scenes, and fun gadgets like robots and hover boards," and the world they live in as "pretty cool."