Clifton Springs Sanitarium is a historic sanitarium building located at the village of Clifton Springs in Ontario County, New York.

[2] Construction of the sanitarium building began in 1892 as a five-story ell-shaped 244-foot-long (74 m) brick structure in the Richardsonian Romanesque style.

The facade is eleven bays wide and terminated at each end by a conical tower with flat roof.

The building includes a chapel that has a favrile glass mosaic of the Last Supper designed by Louis Comfort Tiffany.

The spa building "is a fine example of the early work of the Elmira architectural firm of Pierce & Bickford which was active in the western part of New York State from 1890 to 1930.