[2] In 1861, the Pere Marquette Railway constructed a line through Clio to Flint (now the CSX Saginaw Subdivision) .

[3] The building was purchased by the Clio Area Historic Association in 1977, and was renovated in the 1980s to turn into a museum.

The Clio Depot is a one-story vernacular frame structure clad with clapboard.

Decoration is minimal, confined to the pedimented hoods located above the windows and doors.

This article about a property in Michigan on the National Register of Historic Places is a stub.