The wilderness comprises much of the Clover Mountains and has biome influences from the Tule Desert adjacent to the southeast.

The large Clover Mountain region contains numerous spires, rock outcrops, meandering canyons, and perennial streams.

The peaks in the mountains rise to more than 7,000 ft (2,134 m) with areas of old-growth forest; riparian streams also yield species of ash and cottonwood.

The southern portion of the wilderness contains species from the Tule Desert (Nevada), sagebrush and Joshua Trees.

Some fauna of the region include mountain lion, badger, bobcat, Desert Bighorn Sheep, prairie falcon, and golden eagles.