The club competes in the Championnat Pro A, the top tier of professional basketball in Tunisia.

In 2004, Club Africain won its first Championnat National A championship, after defeating JS Kairouan in the final, 88–87.

Naim Dhifallah scored a buzzer-beater with 0.9 seconds on the clock to bring the team its first national title.

In 2014, the team hosted the FIBA Africa Champions Cup and eventually captured the third place in the tournament.

On March 10, 2024, the Club Africain won the Super Cup of Tunisia 2023 final for the fourth time against the Union Sportive Monastirienne (68-48[2]) at the Radès Sports Hall.