Necaxa, Atlante, Real Club España, Germania, and Asturias were already members of the Liga Mayor de la Ciudad.

Shortly after the Mexican Football Federation was formed in 1928, Rafael Garza Gutiérrez was designated as the head coach of the Mexico national team.

Club América had declined from its then-prime of the 1920s and 1930s: aging players, diminishing financial resources, and resulting lack of interest made the team a bottom-feeder at the start of the beginning stage of the professional era7.

On 21 April 1964, at the Estadio Olímpico Universitario, the team, now coached by Alejandro Scopelli, defeated Monterrey 6–5 in the final match of the Copa México.

América clinched the top of their group in the Prode-85 and defeated Universidad de Guadalajara and Atlante (which was rescheduled following the earthquake suffered in Mexico City)[52] to reach the final, where they faced Jaibos Tampico Madero.

The club also announced the signing of two African players, Cameroon international François Omam-Biyik and Zambia national team captain Kalusha Bwalya.

It was rumored that conflict between the coach and Diez Barosso regarding Beenhacker's defending of playing Del Olmo was the reason for his sacking.

A golden goal from a Hugo Norberto Castillo header in the 107th minute gave América the victory, and the club its first league championship in 13 years.

[63] The club once again reached the league final during the Clausura 2005 tournament, finishing third in the standings and defeating Santos Laguna and Cruz Azul in the quarterfinals and semi-finals to face Tecos UAG.

[69] After finishing third in their group and sixth in the general standings, América played Morelia for the last spot in the playoffs, being beaten 3–0 in the first-leg, and winning 1–0 in the second-leg.

Despite their poor domestic form, América fared well in the Copa Libertadores, defeating Brazilian side Flamengo 3–0 in the round-of-16 at the Estádio do Maracanã, overturning a 2–4 first-leg deficit, and advancing to the quarter-finals.

[78] They defeated Santos FC to reach the semifinal stage of the tournament, being eliminated by eventual champions LDU Quito after drawing 1–1 on aggregate.

On 26 May 2013, América won their eleventh league title by defeating Cruz Azul in the Clausura final 4–2 on penalties after a dramatic comeback from a 0–1 first-leg loss to win 2–1 in the second-leg, and tie 2–2 on aggregate, with goalkeeper Moisés Muñoz scoring the second goal in injury-time.

[96] For the Apertura 2013, América finished the regular phase of the tournament at the top of the standings with 37 points and would again appear in the league final, though failing to achieve a repeat, being defeated by León by an aggregate score of 1–5.

[97] On 17 December 2013, Antonio Mohamed was announced as América's new manager for the Clausura 2014 tournament, replacing Miguel Herrera after two years in charge.

[99] América finished the Apertura 2014 tournament at the top of the general standings with 31 points, and defeated UNAM and Monterrey in the quarter-finals and semi-finals, respectively.

[101] On 14 December, América won a record-twelfth league title after defeating Tigres UANL 3–1 on aggregate in the final, coming back from a 0–1 first-leg loss to win 3–0 in the second-leg at the Estadio Azteca.

[106] In April 2015, the club won its sixth CONCACAF Champions League title after defeating Montreal Impact in the finals by a 5–3 aggregate score.

[118] The team followed this up by winning the 2019 Campeón de Campeones against Tigres UANL and reaching the 2019 Apertura finals, losing 4–2 on penalties to Monterrey.

[121] They defeated León and Atlético San Luis in the quarter-final and semi-final, and beat Tigres UANL 4–1 on aggregate to win a record-extending 14th title and end the club's five-year league drought.

[128] During the Apertura 2011 tournament – what was the club's 95th anniversary – a commemorative jersey was unveiled paying homage to the original uniform, as well as an altered crest.

In an effort to change the fortunes of the club which for years had been struggling financially and was suffering a five-year trophy-less drought, Azcárraga Milmo prioritized high-profile signings of foreign players and executives, notably hiring Guillermo Cañedo de la Bárcena, the successful president of Zacatepec.

Other club sides have also used the stadium as their home at different times, namely Necaxa (1966–70 and 1982–2003), Atlante (1966–82, 1996–2001 and 2004–2007), Universidad Nacional (1967–1969), Atlético Español (1970–1982) and Cruz Azul (1971–1996 and 2018-2023).

[142][143] In a February 2015 poll conducted by the firm Consulta Mitofsky, América was named the most popular club with 31.1 percent of the population being supporters,[144] more than rivals Guadalajara (17.9) and Cruz Azul (12.7) combined.

[148] Its extensive fan base also makes Club América among the most followed teams on social media, ranking third in all of Latin America behind only Brazilian sides Flamengo and Corinthians.

According to a 2020 survey by Gilt Edge Soccer Marketing, América is the ninth most popular team in the U.S., the only non-European in the top ten, and the only one from Latin America.

[153] An emphasis on heavy spending on Mexican and foreign players and managers in subsequent seasons, as well as success in domestic and international competitions, created an increasing sense of enmity from rival fans.

The fact that Azcárraga Milmo was also the owner of telecommunications company Telesistema Mexicano furthered the notion that América was the club of the "establishment" and the "wealthy", while others were considered teams representing the "working class".

[154] Three Club América supporters' groups (barra bravas in Spanish) exist: La Monumental, Disturbio, and Ritual del Kaos.

[180] Alongside Egyptian club Al Ahly, América holds the distinction of being the outright record winner of its domestic league, cup competition, and confederation.