In December 2015, Patronato achieved its second promotion to Primera after defeating Santamarina de Tandil by penalty shoot-out.

On April 5, 2023, Patronato made their debut in the Copa Libertadores, losing by a scoreline of 2-1 against Atlético Nacional.

They ended their Libertadores campaign with 2 wins and 4 losses, but finished 3rd in their group, qualifying for the Copa Sudamericana play-off round, where they lost to Botafogo by 3-1 on aggregate.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.