Although other sports are practised in the club, Quilmes is mostly known for its basketball team, which currently plays in the Liga Nacional de Básquet, the top division of Argentine league system.

Quilmes was founded on April 12, 1922, by a group of young people who used to play football in some of the many unoccupied lands that existed in Mar del Plata in those times.

[1] At the beginning those boys did not have a physical place for their meetings and because of that the Club Ferroviario (founded and integrated by employees of the Buenos Aires Great Southern Railway ("Ferrocarril Sud" in Spanish) allowed them to use their buildings.

Quilmes' first President was Eugenio Moure, who also composed the official anthem of the club along with the musicians Luis Duhalde and Francisco Mafia.

In 1987 Quilmes participated in their first national competition, the LNB "C" (third division), where the squad defeated Regatas (San Nicolás) crowning champion and promoting to "Liga Nacional B".

Coached by Oscar Sánchez, the players that took part of the team were Sebastián Ginóbili, Eduardo Dominé, Leandro Ginóbili, Alejandro Alegretti, Fabián Crivaro, Adolfo Perazzo, Michael Wilson, Mario Romay, Javier Bianchini, Juan Pablo Vignolo, Santiago Cuñado and Adrián Martínez.