Apart from football, other sports hosted by San Miguel are basketball, boxing, field hockey, martial arts, roller skating, swimming, tennis and volleyball.

The institution was established on 7 August 1922 as "Club Independiente San Miguel", while it was decided that the colors of the jersey would be green and white.

In 1977 San Miguel acquired a land in Los Polvorines district of Greater Buenos Aires, where the club built a multi-sports field (which would be inaugurated on 3 September 1978 with a friendly match against Sportivo Italiano).

That same year San Miguel affiliated to Argentine Football Association, debuting in the Primera D tournament.

Journalists Juan Carlutti and Gastón Asiari nicknamed the team "El Trueno Verde" (The Green Thunder) during its first year in the second division due to the great campaign made by the squad.