The club gained notoriety during the 1980s, when its basketball team competed in the first division, winning the last edition of Campeonato Argentino in 1984, prior to creation of Liga Nacional de Básquet.

Apart from basketball, San Andrés hosts the practise of other sports, such as Five-a-side football, karate, swimming, tennis and volleyball.

San Andrés debuted in the Argentine league in 1956, competing in Asociación Porteña de Básquetball (Buenos Aires Basketball Association), with Oscar Loco Ibáñez and Alfredo Stanizewski as its most notable players.

After playing nine years at the top division of Argentine basketball, San Andrés won its first title in 1968 after beating Racing Club by 66-65 at Estadio Luna Park.

Three years later San Andrés won the Campeonato Argentino beating River Plate at the finals, after three games played (2-1 on aggregate).