He entered the majors in 1909 with the New York Highlanders of the American League, playing for them one and a half seasons before joining the Boston Red Sox (1910–14).

In Game 6, he hit a two-run RBI double off Giants pitcher Rube Marquard that scored Boston's only runs in a 5–2 losing effort.

The decisive Game 8 at Fenway Park faced Joe Wood for Boston and Christy Mathewson for the New York Giants, who had broken a 1–1 tie by scoring a run in the first half of the 10th inning.

Snodgrass made a fine catch on the next batter, Harry Hooper, but Mathewson walked Steve Yerkes, gave up a single to Tris Speaker, and Engle went on to score the tying run.

Another walk to Duffy Lewis and a sacrifice fly by Larry Gardner scored Yerkes with the winning run to give Boston the game and the series.