Clyde Wise Smith (July 17, 1904 – December 30, 1982) was an American football player and coach.

He played professionally as a center for four seasons in the National Football League (NFL) with the Kansas City Cowboys (1925–1926), the Columbus Tigers (1927), and the Providence Steam Roller (1928).

He owned the Lawrenceville Greenhouses, was chaired the Lawrence Country Housing authority, and was a board member of the Lawrence County Chamber of Commerce.

Smith died on December 30, 1982, at his home in Lawrenceville, Illinois.

This biographical article relating to an American football offensive lineman born in the 1900s is a stub.