The Co-Cathedral of the Nativity of the Blessed Virgin Mary was until 2020 the mother church of the Roman Catholic Diocese of Juneau and is currently a cathedral of the Roman Catholic Archdiocese of Anchorage-Juneau.

The church was consecrated and elevated to the status of cathedral in 1951, when the Diocese of Juneau was created.

[1][2] Robert Dermot O'Flanagan was appointed the first Bishop of Juneau, having served as a priest in Alaska since 1933.

[4] In 2019, fundraising began for a major renovation of the cathedral with support from Andrew E.

The church building is now the co-cathedral of the archdiocese, along with Our Lady of Guadalupe Cathedral in Anchorage, Alaska.