Future Chicago White Sox major league pitcher Brad Goldberg played for the team in 2009-10, making 18 appearances (17 in relief) in those two seasons.

In the 2016 post-season, Coastal won the Raleigh Regional by beating the NC State Wolfpack 2-1.

The Chanticleers went on to beat the LSU Tigers 2-0 in the Baton Rouge Super Regionals, and ultimately got to the 2016 CWS Final and defeated Arizona two games to one to win the National Championship.

On June 30, 2016 the Coastal Carolina Chanticleers defeated Arizona 4-3 in game 3 to become the 2016 NCAA Men's Baseball Champions.

In all, the university has produced 11 players on active MLB rosters, beginning with Mickey Brantley in 1987.