It runs directly through the two sides of Mount Moriah Cemetery which spans the border of Southwest Philadelphia and Yeadon, Pennsylvania.

Additionally, at the mouth of Mill Creek, a neighboring water source, there existed village named "Arronemink," meaning "where the fish cease."

Nitre Hall Powder Mills were built in the early 19th century along Cobb's Creek on Karakung Drive.

For many in West Philadelphia, Cobbs Creek is the primary hiking and recreation attraction, offering swimming, golf, ball fields, tracks, tennis and basketball courts, ice and roller hockey rinks, and campgrounds.

Nomenclature such as that of Kingsessing (derived from the Lenape term "Chingsessing," meaning "where there is meadow")[11] demonstrate the indigenous legacy still prevalent in the area.

Local schools run service learning activities to support conservation in the creek and surrounding parks; e.g., conducting water-quality studies to track pollution.

The wildlife includes regional birds, raccoons, opossums, spotted deer, wild turkey, rabbits, and in recent history, even a mountain lion.