The city was founded in 1863 by General Justo José de Urquiza, former caudillo of Entre Ríos and then the first constitutional President of Argentina.

The neighboring towns allow for small-scale historical sightseeing, since they were mostly created as agricultural colonies by European immigrants (especially from Switzerland).

The Palacio San José, former country residence of General Urquiza and now a national monument, is also near Colón, closer to the city of Concepción del Uruguay.

The "Parque Quirós" is an elevated park with a large variety of fields to practice several sports such as association football, tennis, basketball, rugby union, among others.

[4] It was built by national deputy (and then governor of Entre Ríos) Herminio Quirós as a sports center for the schools of the city.