In the south, the road begins at a level of 2,057 m Col du Lautaret, which connects Grenoble in the west with Briançon in the east.

From the north, starting at Saint-Michel-de-Maurienne (including the Col du Télégraphe), the climb is 34.8 kilometres (21.6 mi) long, gaining 2,120 metres (6,960 ft) in height (an average of 6.1%).

The actual climb to the summit starts at Valloire and is 18.1 kilometres (11.2 mi) long at an average of 6.9% (height gain: 1,245 metres (4,085 ft)).

At the south portal of the tunnel, at the edge of the road, there is a monument to Henri Desgrange, instigator and first director of the Tour de France.

As a result of snow on both the Col de l'Iseran and the Col du Galibier, the scheduled 190 km stage from Val-d'Isère to Sestriere in Italy was reduced to a 46 km sprint from Le-Monetier-les-Bains which was claimed by Bjarne Riis, resulting in him taking the yellow jersey which he retained to the finish in Paris.

In the 2008 Tour, the Col du Galibier had been crossed on 23 July in the 210 km stage 17 from Embrun to Alpe d'Huez.

[4] It was scheduled to be used again in stage 20 of the 2015 Tour, but was left out nine days before the race start due to landslides in the Chambon Tunnel, situated towards the bottom of the descent of the climb.

[5] The 2013 Giro d'Italia climbed the Col du Galibier, although the stage had to be shortened by 4 km due to heavy snowfall.