They are best known for their cabaret work and appearances on the television series Difficult People (2015–2017), At Home with Amy Sedaris (2017–2020), Search Party (2020–2021), and Big Mouth (2022), as well as for writing and starring in the play Oh, Mary!

[2] When they were six, their father chased the entire family out of their mobile home with a gun,[3][4][5] after which Escola, their mother, and their brother subsequently lived in government housing.

Escola participated in community theater and starred in high school productions of Fiddler on the Roof, Les Misérables, and Little Shop of Horrors.

Long High School in 2005, Escola moved to New York City to study humanities at Marymount Manhattan College, dropping out after one year.

[13] In 2008, Escola met fellow comedian Jeffery Self in New York; bonding over a shared love of theater and 1990s sitcoms, they began creating surreal, semi-scripted YouTube videos under the moniker "Very Good Looking (VGL) Gay Boys."

The sketches, in which Escola often played the demented comic foil to Self's straight man,[14] received over 100,000 views, prompting coverage in New York magazine and a development deal from Logo TV.

[4] Their wigs often shape and inform their recurring stage characters, which include Broadway performer Bernadette Peters, suicidal homemaker Joyce Conner, scheming furniture heiress Jennifer Convertibles, and The Goblin Commuter of Hoboken.