In the year before his Ontario Hockey League (OHL) eligibility, Perfetti led them in scoring with a total of 52 goals and 73 assists for 125 points.

Due to the COVID-19 pandemic, his sophomore season was cut short and he joined the Jets' American Hockey League (AHL) affiliate, the Manitoba Moose, to start his professional career.

In the year before his Ontario Hockey League (OHL) eligibility, Perfetti led them in scoring with a total of 52 goals and 73 assists for 125 points.

[6] As a result of his GTHL play, Perfetti was recruited to join the University of Michigan's men's ice hockey team for the 2018–19 season.

[8] As the season progressed, Perfetti continued to produce offensively and quickly surpassed Jan Mursak to set a new franchise record for most goals scored by a rookie.

[10] He earned this honour again in March after leading all rookies with seven goals and four assists through eight games to help the Spirit secure its first West Division title since 2011.

[11] Although Perfetti helped the Spirit qualify for the OHL playoffs, they were eliminated in Game Seven of the Western Conference Championship Series by the Guelph Storm.

As a result of his play, Perfetti was named to 2019-20 OHL Second All-Star Team and ranked fourth among North American skaters eligible for the 2020 NHL Draft.

[19] Following the signing of his entry-level contract, Perfetti joined the Jets' American Hockey League (AHL) affiliate, the Manitoba Moose, for the 2020–21 season.

[29] In a game the day prior on December 30, Wild star Kirill Kaprizov was injured from a pair of cross-checks from Jets defenceman Brenden Dillon.

[31] On January 2, 2024, the NHL fined Hartman $4,427.08 for high-sticking Perfetti, the maximum allowable under the league's collective bargaining agreement for an infraction which does not involve an injury or game misconduct penalty resulting from a play.

[37] He was invited to participate in Team Canada's camp for the 2020 World Junior Ice Hockey Championships but was cut before the final roster decisions.

[42][43] Craig Button of TSN described Perfetti as "an elite scoring left winger in the mold of New York Rangers star Artemi Panarin.

[42] During the COVID-19 pandemic, Perfetti started a non-profit organization called "Fetts’ Friends" to provide meals to the Environmental Service and Supply Chain employees at Covenant HealthCare.