Colegio Mayor de San Bartolomé is a private Catholic pre-school, primary and secondary school, colonial of Plateresque style building, located in the Santa Fe district of Bogotá, Cundinamarca, Colombia.

Colegio Mayor de San Bartolomé, with its more than 412 years of existence, made a very significant contribution to Colombian society in the independence epoch.

Its baccalaureate building is a cultural and national monument by Decree 1584 of 11 August 1975,[1] and is located diagonally across from the southeast corner of Bolivar Square in Bogota.

This building along with the Church of St.Ignatius and the Museum of Colonial Art in Bogota are part of the Jesuit block, which has been under restoration by the Society of Jesus and the Colombian Ministry of Culture.

On 23 September 1604 six Jesuits came to Santafé from Cartagena to found the College of the Society of Jesus with support from the Archbishop of Bogota Don Bartolomé Lobo Guerrero.

The educational institution, although it was originally called the College of the Society of Jesus in Santa Fe, today is called the St. Bartholomew Major College, a name inherited from the seminary of the city re-founded by the Archbishop Don Bartolomé Lobo Guerrero on 18 October 1605 and located in what is now the Palacio de San Carlos.

The seminarians and the borders both took their classes in the College of the Society of Jesus in Santa Fé, and called it the School and Seminary of St. Bartholomew.

By a bull of Gregory XV and by a royal document from Felipe IV issued in 1622, the College established itself as Xaverian University.

In the year 1902, President Jose Manuel Marroquín and Archbishop Bernardo Herrera Restrepo, officially consecrated the nation to the Sacred Heart of Jesus on June 22.

[citation needed] With the possibility of expropriation of the school building, the Jesuits built a new one on La Merced farm.