[2] Clarke joined Wigan at the age of 17 from Orrell rugby union club, making his debut in 1963.
[5] Colin Clarke played hooker in Wigan's 20–16 victory over Hunslet in the 1965 Challenge Cup final during the 1964–65 season at Wembley Stadium, London on Saturday 8 May 1965, in front of a crowd of 89,016.
[6] Wigan returned to Wembley the following year in the 1966 Challenge Cup, but Clarke missed the final due to suspension.
[5] Clarke played hooker, and scored a try in Wigan's 16–13 victory over Oldham in the 1966 Lancashire Cup final during the 1966–67 season at Station Road, Swinton, on Saturday 29 October 1966.
Clarke played hooker in the 15–8 victory over Widnes in the 1971 Lancashire County Cup final during the 1971–72 season at Knowsley Road on Saturday 28 August 1971,[9] and played hooker in the 19–9 victory over Salford in the 1973 Lancashire Cup final during the 1973–74 season at Wilderspool Stadium, Warrington, on Saturday 13 October 1973.