He also played General Zod on the Syfy series Krypton and provided his voice and likeness as Agent Carson in the PlayStation VR video game Blood & Truth.

Speaking about his quartet to Pete Lewis of the magazine Blues & Soul, in an interview prior to their performance at the Cheltenham Jazz Festival in May 2008, Salmon stated: In terms of recording, we've done none.

And what's made that particularly difficult in the last year, for example, is that I've literally just spent an entire 12 months travelling the world acting – from China through to Montreal to Botswana.

In 2006 he appeared in the eighth series of the ITV drama Bad Girls as Senior Medical Officer Dr. Rowan Dunlop.

His other film credits include Captives (1994), Frantz Fanon: Black Skin White Mask[14] (a documentary directed by Isaac Julien in which Salmon plays the French psychiatrist, philosopher and revolutionary, Frantz Fanon) (1996), The Wisdom of Crocodiles (1998), Fanny and Elvis (1999) and My Kingdom (2001).

In 2009, Salmon appeared in the UK version of the popular American drama Law & Order, as barrister Doug Greer in the episodes "Buried" and "Community Service".

[15] Salmon was one of the celebrity contestants on the tenth series of BBC One's Strictly Come Dancing, partnered with professional dancer Kristina Rihanoff.

In 2015, he played a fictional version of himself in the Netflix series Master of None, alongside Aziz Ansari's main character.

In 2023, Salmon joined the cast of the BBC soap opera EastEnders as George Knight, a newly introduced co-owner of the Queen Vic.

[21][22] In September 2010, Salmon was invited by his friend Samuel L. Jackson to Switzerland for Shooting Stars Benefits 2010 Golf Tournaments.

[24] In an August 2021 interview, Salmon spoke about how becoming ill with COVID-19 had affected him and his family, praising doctors for having saved his life.