[6][7] Previously a women's college, the board of trustees voted unanimously to become co-educational in September 2022[8] and admitted its first undergraduate men in the fall semester of 2023.

[13] In December 2024, the parties announced that they "continue to make progress during the transition period ... before final approval of a merger of MUIH into NDMU by the U.S. Department of Education (USDE).

It borders to the south, Evergreen Museum & Library, the historic landmark Greek Revival styled mansion of the Garrett family.

Adjacent to the Montrose House (1850) on the original property site purchased by the School Sisters of Notre Dame, one of the first buildings, "Gibbons Hall," was constructed in an "L-shaped" structure.

The university's Marikle Chapel of the Annunciation was originally designed by notable architects Ephraim Francis Baldwin and Josias Pennington.

The renamed "Noyes Alumnae House", which was the former Montrose estate of a red brick Greek Revival style of architecture was built in 1850,[clarification needed] on the southwest corner of the campus.

All sports but swimming joined the Colonial States Athletic Conference (CSAC) starting in the 2007-2008 academic year.