It primarily serves students from within the Micronesian region and is designated as the national post-secondary institution for the Republic of the Marshall Islands (RMI), as enacted in RMI PL 1992-13, The College of the Marshall Islands Act.

[citation needed] The main campus of the College of the Marshall Islands is located in Uliga, Majuro Atoll.

The College Administration Offices and the Library are located in the buildings formerly used as a hospital, as are some classrooms.

Adjacent buildings house Land Grant Cooperative Research and Extension programs and PEACESAT administration, Upward Bound and College Achievement Project (SSSP).

Oscar deBrum Hall, redeveloped and given that name in late 1999, houses the Continuing Education program on the first floor and faculty offices on the second.