It occupies an alluvial plain at the end of the Val di Susa, between Rivoli and Turin, at the foot of Monte Musinè.

Collegno originated as a Roman mansio 8 kilometres (5 mi) from Turin, known as Quintum Collegium (hence the modern name).

From an ancient Roman villa, a richly decorated church was built at the beginning of the 5th century AD, dedicated to San Massimo, the first bishop of Turin.

[4] In 2002, during excavations for the construction of the terminal of line 1 of the Turin Metro, the remains of a Langobard settlement and necropolis came to light.

[6][7] In 1641, Maria Cristina of France, regent of Savoy Dukedom, ordered the edification of a "Charterhouse" to host a monastery; the large building was designed by M. Valperga, the First Ducal Architect and completed by Juvarra.