He was sworn in for a third term of office on 2 January 2019 as councillor for social affairs in the government of Mayor Bart Tommelein at the Ostend City Council in West Flanders province.

He later led a team of students on internship from the University College of West-Flanders in the development of a resource center with employment services tailored towards the labour market needs of ethnic minority groups in 2004, culminating in a highly successful national conference of private–public partners.

He was co-founder, in collaboration with Reginald Moreels [nl], then Belgian Minister of International Development, of the Jakoeboe Refugee Welfare Association in Ostend.

Nweke played a leading role[5] in researching and managing the Nigerian Diaspora input in the 2005 National Political Reforms Conference (NPRC) in Nigeria.

In 2018 he was shortlisted for consideration by President Muhammadu Buhari for the position of director-general of the new Nigerian Diaspora Commission according to African Courier Magazine Germany As chairman, Nweke focused on trade and investment and the engendering of sustainable strategic management processes.

Nweke was advisor to the Government of Nigeria on the role of the Diaspora in national development[8] and consults for a number of public and private sector entities.

He worked as lead consultant for the African Diaspora Investment Forum in London, originated by NEPAD (New Partnership for Africa's Development), and for the Commonwealth Business Council.

In this capacity he facilitated meetings of Africa Parliamentary Committees in the UK, France, Italy, Germany, Japan and USA with African political leaders.

He appeared on 1 April 2014 on the BEN TV London program 'You Decide' promoting issues around youth political empowerment in Nigeria and employment.

He went on to be elected the founding chairman of the advisory board but resigned after about a year, frustrated at the lack of opportunity provided by the municipal authority and the civil service for him to carry out his functions.

The African Ripple Magazine[22] reported that on 4 June 2016, Collins Nweke was honoured with the Award of "Ambassador of Integration and Diversity" and handed a Charter to that effect by Mayor Hilde Claes [nl] at a ceremony in Hasselt, Belgium.

[30] In the Dutch-language book De Keizer van Oostende [nl],[31] Nweke was credited with bringing about a spirited opposition and debate in the Council for Social Affairs which did not exist before his time.

In the Council Session of 7 December 2011, Collins Nweke initiated a campaign to end the practice of preferential treatment for children of councillors in the allocation of places for student jobs.

[33] Early in 2014, Nweke expressed concern about the efficiency of the State Owned Enterprise (SOE), Economisch Huis Oostende (House of the Economy Ostend)[34] in delivering its corporate goals despite considerable resources which the council had invested in it.

[35][36] A breakaway local political party OK, led by the former chairman of New Flemish Alliance (N-VA) Hendrik Wallijn in an interview in a national daily De Standaard of 20 September 2018[37] disclosed that unable to gather sufficient signatures to have their party registered for participation in the municipal election of 14 October 2018, outgoing Councillor Collins Nweke had come to their rescue by accepting to sign the relevant acts.

On 24 October 2014, Collins was the only councillor out of 41 who joined a consortium of civil society organisations for a trip to Ramsgate and Canterbury (United Kingdom) agitating for the resumption of ferry services between Ostend and England.

On 10 November 2014 Collins Nweke convened and inaugurated[44] the Africa Social Policy Reform Summit at the European Parliament, hosted by Bart Staes.

He participated in solidarity with trade unionists in the national strike of 15 December 2014 subsequently publishing an article Cutting Close to the Bones of Workers under his Socio-Economic Policy Briefing series on his website.