Both countries are full members of the Rio Group, the Latin Union, the Association of Spanish Language Academies, the Organization of American States, the Organization of Ibero-American States, the Community of Latin American and Caribbean States, the Cairns Group, and the Group of 77.

[1] On July 25, 1980, the Joint Commission for Economic, Technical, Scientific and Cultural Cooperation was created by an exchange of notes by the Ministers of Foreign Affairs Diego Uribe Vargas and Rafael Castillo Valdez.

[1] On January 17, 2023, the government of Guatemala accused Colombia's defense minister Iván Velásquez Gómez of corruption, which sparked tensions between the two nations.

The products exported from Guatemala to Colombia included Industrial Fatty Acids, Oils and Alcohols ($28.4M), Raw Sugar ($27.5M), and Pesticides ($13.3M).

The products exported from Colombia to Guatemala were Coal Briquettes ($173M), Refrigerators ($26.5M), and Raw Plastic Sheeting ($18.5M).