Colombia competed at the 2022 World Athletics Championships in Eugene, United States, from 15 to 24 July 2022.

Without having won any medal, Colombia ranked 73rd place in the overall placing table with one point, achieved thanks to Éider Arévalo's eighth place in the men's 35 kilometres race walk.

It was the first time since Berlin 2009 that Colombia did not win a medal.

[2] Originally, Colombia entered 14 athletes qualified for the World Athletics Championships;[1] however, the Colombian team was eventually reduced to 7 athletes after the withdrawals of the team for men's 4 × 400 metres relay event (conformed by Gustavo Barrios, Raúl Mena, Jhon Perlaza, Jelssin Robledo, Nicolás Salinas and Jhon Solís) and the javelin thrower Flor Ruiz, all of whom were unable to obtain a visa to enter the United States (except for Raúl Mena).

[3][4] Other notable absences for Colombia (due to injuries) included the sprinter Anthony Zambrano and the racewalker Sandra Arenas, both silver medalists at Tokyo 2020.