Colony's Block is a historic commercial building at 4-7 Central Square in the heart of Keene, New Hampshire.

The five-story brick building was built in 1870 to a design by Worcester, Massachusetts, architects E. Boyden & Son, and is the city's most prominent example of Second Empire architecture.

The ground floor consists of three modernized storefronts, each with a recessed entrance and large display windows.

It was built by Timothy Colony, treasurer of the Cheshire Mills of Harrisville and a prominent local businessman.

The building was designed by Elbridge Boyden of Worcester, Massachusetts, who had executed other commissions in Keene prior to this work.