[citation needed] Colony High School has a wide array of classes and clubs revolving around the arts: Art, Ceramics, Music Appreciation, Digital Media, Drama & Theatre, Choir, Dance, Marching Band, Jazz Band, Percussion, and Color Guard classes.

The Colony High School Titan Regiment consists of a band, percussion, and color guard.

Among their past productions are Dracula, Grease, Black Comedy, Metamorphoses, Noises Off, West Side Story, You Can't Take It with You, Taming of the Shrew, A Christmas Carol, Lend Me A Tenor, Once on this Island, Leading Ladies, The Diviners, Tartuffe, The Elephant Man (play), Blithe Spirit (play) and a variety show titled 30/60 (which features a cast of seven performing thirty original skits in sixty minutes, hence the name 30/60).

Colony High School's sports program includes baseball, basketball, cheer, cross country, football, golf, swimming, soccer, tennis, track, volleyball, water polo, softball, and wrestling, and cross country running.

In the graduating class of 2007 there were several D-1 football players, including Omar Bolden (Arizona State University), NFL players Bobby Wagner, Josh Andrews, Omar Bolden, and Khalil Dorsey are Colony High School Alumni.