[4][5] The territory that is now Colorado County has been continually inhabited by humans for at least 12,000 years.

The first record of a European coming through the area that is now Colorado County was January 20, 1687, when René Robert Cavelier, Sieur de La Salle, camped along Skull Creek.

The fourth expedition of Alonso De León may have crossed into the area while looking for Fort St. Louis in 1689.

[6] The area was settled by Anglo colonists who were part of Stephen F. Austin's Old Three Hundred starting in 1821.

Some families settled near Beeson's Ford, a few miles south of Columbus' present day location.

[6] Dilue Rose Harris wrote her memoir of the Runaway Scrape from within the boundaries of Colorado County.

The last Democrat to carry the state was Jimmy Carter in 1976; George W. Bush, Mitt Romney and Donald Trump all received more than 70 percent of the vote in the county.