While centering the Admirals' first line, Sissons was selected for the 2014 AHL All-Star Game after being tied for second amongst league rookies with 13 goals.

[3] During the 2008–09 season, Sissons was the youngest forward on the Vancouver NW Giants of the BC Hockey Major Midget League.

[4] At the age of 15, Sissons was drafted by the Saskatoon Blades of the Western Hockey League (WHL) but he was unsure if he wanted to forgo his NCAA eligibility by signing with them.

[3] While playing midget ice hockey in Vancouver, he was teammates with future Edmonton Oilers player Ryan Nugent-Hopkins.

[5] Following this, Sissons competed with the British Columbia Hockey League's Westside Warriors, where he tallied six goals and 22 points through 58 games.

[15] After attending the Predators' 2013 training camp, Sissons was re-assigned to their American Hockey League (AHL) affiliate, the Milwaukee Admirals, for the 2013–14 season.

His maturity earned him praise from Admirals coach Dean Evason, who said: "It's as if he's been a 10-year pro in how he goes about his business, how he prepares for games, and how he is with his teammates off the ice.

[26] Prior to the start of the 2015–16 season, Sissons became the first forward since Tony Hrkac to be named captain for the Admirals alongside alternates Cody Bass and Coner Allen.

[30] By February 2016, Sissons had tallied two points through 19 appearances for the Predators and had a 59 percent success rate in face-offs to rank the best among all NHLers taking at least 100 draws.

He was eventually teamed up with captain Mike Fisher and Austin Watson for the Predators shutdown line and scored his first career NHL hat-trick in January.

[39] As the Predators narrowly qualified for the 2017 playoffs as the eighth seed in the Western Conference, they met the top-seeded Chicago Blackhawks in the first round.

In Game 2, Sissons scored his first career playoff goal on Blackhawks' goaltender Corey Crawford to become one of four Predators players (besides Ryan Ellis, Kevin Fiala and Harry Zolnierczyk, respectively) to score their first career playoff goals and lead the team to a 5–0 win in the game for a 2–0 series lead.

Due to injuries to top-line forwards Ryan Johansen and Mike Fisher, Sissons was elevated to the first-line role in Game 5 of the Western Conference Final.

[43] During Game 6, he scored a hat-trick—including the game-winning goal—as the Predators defeated the Ducks 6–3 to win the Clarence S. Campbell Bowl trophy and advance to the Stanley Cup Finals for the first time in franchise history.

[44] Sissons also set another record by becoming the first player to score a hat trick in a series-clinching win in the conference final since Patrick Kane in 2013.

[46] During Game 5 of the Finals, which the Penguins won 6–0, Sissons received a Match penalty after cross-checking Olli Maatta with 34 seconds remaining in the period.

[51] During their first round playoff series against the Colorado Avalanche, Sissons played on the Predators top-line alongside Nick Bonino and Austin Watson.

[57] Sissons began the month of October on the Predators fourth line between Zac Rinaldo and Miikka Salomaki as the team held a 5–1–0 record.

[67] While staying in the Edmonton Bubble, Sissons worked with Predators reporter Adam Vingan to write a diary entry for The Athletic depicting his experiences.

[70] A few games later, Sissons tallied his 100th career NHL point with an assist on Nick Cousins's goal to beat the Detroit Red Wings 7–1.

[71] At the end of the month, Sissons was tied with Rocco Grimaldi for fourth in scoring on the Predators with seven, behind Mikael Granlund, Viktor Arvidsson, and Roman Josi.

[72] He suffered a lower body injury in early May and missed one game before returning to the ice for a loss to the Columbus Blue Jackets.

Following their elimination, the Predators released their player protection list ahead of the 2021 NHL Expansion Draft which did not include Sissons.