Thanks to this movie Columba rose to stardom rapidly and became known worldwide to be presented at the Karlovy Vary International Film Festival.

[citation needed] Encased in native roles, Columba separates professionally from Fernandez in 1952, which allowed them to become one first figure and work under the orders of other filmmakers, such as Luis Buñuel (with whom she worked in El río y la muerte (1955)), Fernando Méndez (director of the cult film Ladrón de cadáveres (1957), considered one of the best Mexican horror films) and Ismael Rodriguez (who took her to star in two masterpieces: Los Hermanos de Hierro (1961) and Ánimas Trujano (1962), with the Japanese actor Toshiro Mifune), among others.

In 2008, after more than 20 years of retirement from cinema, the Mexican director Roberto Fiesco returned her to the screen in the short film Paloma.

That same year, Dominguez was honored by the International Film Festival de la Frontera, in Ciudad Juarez, at which some of the most representative titles in which she performed were shown.

[citation needed] In May 2013, Columba Domínguez was honored with the Golden Ariel Award for her contributions to the Mexican film industry.

[citation needed] A tragic event marred Domínguez' life when, in 1978, her daughter Jacaranda died after falling from the fourth floor of a building, in circumstances that were never clarified.

[citation needed] After Fernández' death in 1986, a dispute over his will erupted, particularly concerning his stunning "fortress" home in the neighborhood of Coyoacan, in the south of Mexico City.

[citation needed] Her very Mexican beauty was portrayed in paintings by famous artists like Miguel Covarrubias, Jesús Guerrero Galván and Diego Rivera.