[3] Columbus Public Health is headquartered at 240 Parsons Avenue, a large building completed in 1874 for the Ohio Asylum for the Blind.

The building and its campus were listed on the National Register of Historic Places in 1973, and as part of the Columbus Near East Side District in 1978.

[1][4] The building was individually listed on the National Register of Historic Places in 1973, and added to the new Columbus Near East Side District in 1978.

[4] The campus has numerous smaller structures, including a large parking garage and two former dormitory buildings.

The south dormitory building was proposed for demolition in September 2021, to make room for a surface-level parking lot.